Henry Sutton

Jul 31, 2024 | nature.com | Sydney I. Ramirez |Farhoud Faraji |Henry Sutton |Erica Ollmann Saphire |Hyun Kim

AbstractThe upper airway is an important site of infection, but immune memory in the human upper airway is poorly understood, with implications for COVID-19 and many other human diseases1,2,3,4. Here we demonstrate that nasal and nasopharyngeal swabs can be used to obtain insights into these challenging problems, and define distinct immune cell populations, including antigen-specific memory B cells and T cells, in two adjacent anatomical sites in the upper airway.

Jan 15, 2024 | cell.com | Henry Sutton |Xin Gao |Hannah Kelly |Brian Parker

• None The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. :• None Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts. :• None Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells.

Jan 30, 2023 | nature.com | Henry Sutton |Chris Cottrell |Ivy Phung |Gabriel Ozorowski |Jonathan Torres |Wen-Hsin Lee | +10 more

Author notesThese authors contributed equally: Jeong Hyun Lee, Henry J. SuttonAuthors and AffiliationsCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USAJeong Hyun Lee, Henry J. Sutton, Ivy Phung, Catherine Nakao, Kimberly M. Cirelli & Shane CrottyConsortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USAJeong Hyun Lee, Henry J. Sutton, Christopher A.