Farhoud Faraji

Jan 8, 2025 | nature.com | Farhoud Faraji |Sydney I. Ramirez |Kuniaki Sato |Kenneth Kim |Quinton Smith |Ophir Klein

AbstractTumor initiation represents the first step in tumorigenesis during which normal progenitor cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo, however, remains elusive. Here we employ spatiotemporally controlled oncogene activation and tumor suppressor inhibition together with multiomics to unveil the processes underlying oral epithelial progenitor cell reprogramming into tumor initiating cells at single cell resolution.

Jul 31, 2024 | nature.com | Sydney I. Ramirez |Farhoud Faraji |Henry Sutton |Erica Ollmann Saphire |Hyun Kim

AbstractThe upper airway is an important site of infection, but immune memory in the human upper airway is poorly understood, with implications for COVID-19 and many other human diseases1,2,3,4. Here we demonstrate that nasal and nasopharyngeal swabs can be used to obtain insights into these challenging problems, and define distinct immune cell populations, including antigen-specific memory B cells and T cells, in two adjacent anatomical sites in the upper airway.