Hiba Douja Chehade

Jul 24, 2024 | biorxiv.org | Liqiang Chen |Hiba Douja Chehade |Hong-Yuan Chu

AbstractDysfunction of the cerebral cortex is thought to underlie motor and cognitive impairments in Parkinsons disease (PD). While cortical function is known to be suppressed by abnormal basal ganglia output following dopaminergic degeneration, it remains to be determined how the deposition of Lewy pathology disrupts cortical circuit integrity and function.