Hong-Yuan Chu

Jan 14, 2025 | nature.com | Liqiang Chen |Hong-Yuan Chu

ΑbstractIn Parkinson’s disease (PD), Lewy pathology deposits in the cerebral cortex, but how the pathology disrupts cortical circuit integrity and function remains poorly understood. To begin to address this question, we injected α-synuclein (αSyn) preformed fibrils (PFFs) into the dorsolateral striatum of mice to seed αSyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons.

Jul 24, 2024 | biorxiv.org | Liqiang Chen |Hiba Douja Chehade |Hong-Yuan Chu

AbstractDysfunction of the cerebral cortex is thought to underlie motor and cognitive impairments in Parkinsons disease (PD). While cortical function is known to be suppressed by abnormal basal ganglia output following dopaminergic degeneration, it remains to be determined how the deposition of Lewy pathology disrupts cortical circuit integrity and function.

Jul 22, 2023 | biorxiv.org | Liqiang Chen |Samuel Daniels |Rachel Dvorak |Hong-Yuan Chu

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