-
Jan 14, 2025 | 
nature.com | Liqiang Chen |Hong-Yuan Chu
ΑbstractIn Parkinson’s disease (PD), Lewy pathology deposits in the cerebral cortex, but how the pathology disrupts cortical circuit integrity and function remains poorly understood. To begin to address this question, we injected α-synuclein (αSyn) preformed fibrils (PFFs) into the dorsolateral striatum of mice to seed αSyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons.
-
Nov 18, 2024 | 
mdpi.com | Shaojie Wu |Liqiang Chen |Pengxin Guo |Shenlan Zhang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
-
Sep 3, 2024 | 
pubs.rsc.org | Shenglan Zhang |Liqiang Chen |Yuxin Tan |Shaojie Wu
Deep learning assisted quantitative detection of cardiac troponin I in hierarchical dendritic copper-nickel nanostructures lateral flow immunoassay
The rising demand for point-of-care testing (POCT) in disease diagnosis has made LFIA sensors based on dendritic metal thin film (HD-nanoMetal) and background fluorescence technology essential for rapid and accurate disease marker detection, thanks to their integrated design, high sensitivity, and cost-effectiveness.
-
Aug 6, 2024 | 
mdpi.com | Ya Liu |Jiping Gao |Min Zhong |Liqiang Chen
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
-
Jul 25, 2024 | 
mdpi.com | Liqiang Chen |Jiping Gao |Wenzhong Zhang |Hongfang Jiang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
-
Jul 24, 2024 | 
biorxiv.org | Liqiang Chen |Hiba Douja Chehade |Hong-Yuan Chu
AbstractDysfunction of the cerebral cortex is thought to underlie motor and cognitive impairments in Parkinsons disease (PD). While cortical function is known to be suppressed by abnormal basal ganglia output following dopaminergic degeneration, it remains to be determined how the deposition of Lewy pathology disrupts cortical circuit integrity and function.
-
May 23, 2024 | 
biorxiv.org | Donald Doherty |Liqiang Chen |Yoland Smith |Thomas Wichmann
AbstractDecreased excitability of pyramidal tract neurons in layer 5B (PT5B) of primary motor cortex (M1) has recently been shown in a dopamine-depleted mouse model of parkinsonism. We hypothesized that decreased PT5B neuron excitability would substantially disrupt oscillatory and non-oscillatory firing patterns of neurons in layer 5 (L5) of primary motor cortex (M1). To test this hypothesis, we performed computer simulations using a previously validated computer model of mouse M1.
-
Apr 11, 2024 | 
mdpi.com | Wanlin Chen |Jie Zhang |Liqiang Chen |Kehan Miao
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
-
Mar 4, 2024 | 
mdpi.com | Yuzhuo Liu |Wei Xin |Liqiang Chen |Yuqi Liu
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
-
Nov 18, 2023 | 
mdpi.com | Daniel Wilson |Liqiang Chen
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
