Holger Hummerich

Jul 21, 2024 | medrxiv.org | Fahri Küçükali |Elizabeth Hill |Tijs Watzeels |Holger Hummerich

AbstractBackground and ObjectivesPrions are misfolded prion protein assemblies that cause several fatal and transmissible neurodegenerative diseases, with the most common phenotype in humans being sporadic Creutzfeldt-Jakob disease (sCJD). However, aside from the prion protein itself, molecular risk factors are not well understood. Prion and prion-like mechanisms are thought to underpin common neurodegenerative disorders meaning that the elucidation of mechanisms could have broad relevance.