Hong Zhi Zhang

Jul 26, 2024 | nature.com | Lifeng Chen |Jingjing Zhang |Weibin Xu |Jiayi Chen |Yujun Tang |Si Xiong | +3 more

AbstractRespiratory syncytial virus (RSV) hijacks cholesterol or autophagy pathways to facilitate optimal replication. However, our understanding of the associated molecular mechanisms remains limited. Here, we show that RSV infection blocks cholesterol transport from lysosomes to the endoplasmic reticulum by downregulating the activity of lysosomal acid lipase, activates the SREBP2–LDLR axis, and promotes uptake and accumulation of exogenous cholesterol in lysosomes.

May 13, 2024 | rgsa.openaccesspublications.org | Hong Zhi Zhang |Muhammad Khan

Abstract Introduction: This research studied the mediating role of job autonomy in the relationship between ethical leadership and knowledge workers’ innovative behaviour based on self-determination theory. Data were collected from 377 knowledge workers in the IT industry in Sichuan, Henan, and Guangdong province, China. A conceptual model was constructed and tested with the statistical software SMART-PLS.

Apr 20, 2024 | nature.com | Hong Zhi Zhang

AbstractSimulated moving bed (SMB) technology is considered one of the most successful techniques in chromatographic separation. However, due to the nonlinearity caused by discrete events and sensitivity to numerous separation performance parameters, purity control in SMB systems has been a challenging issue. Fuzzy controllers are increasingly popular in industrial environments due to their simplicity and effectiveness in handling nonlinearity.

Apr 7, 2024 | nature.com | Hong Zhi Zhang

Light-emitting perovskite solar cells are emerging optoelectronic devices that integrate light-emitting and electricity-generating functions in one device. This type of device unlocks new possibilities for applications as outdoor light sources, in multifunctional architecture, smart automobiles, self-powered displays and portable power floodlights.

Feb 20, 2024 | nature.com | Chao Sun |Hong Zhi Zhang

AbstractDysregulation of anti-apoptotic and pro-apoptotic protein isoforms arising from aberrant splicing is a crucial hallmark of cancers and may contribute to therapeutic resistance. Thus, targeting RNA splicing to redirect isoform expression of apoptosis-related genes could lead to promising anti-cancer phenotypes. Glioblastoma (GBM) is the most common type of malignant brain tumor in adults.