Hua Bai

Jan 15, 2025 | nature.com | Hua Bai |Guangyu Wang |Cameron J. Nowell |Nicolas H Voelcker |Bo Peng |Lin Li

AbstractMitochondrial morphology and function are intrinsically linked, indicating the opportunity to predict functions by analyzing morphological features in live-cell imaging. Herein, we introduce MoDL, a deep learning algorithm for mitochondrial image segmentation and function prediction. Trained on a dataset of 20,000 manually labeled mitochondria from super-resolution (SR) images, MoDL achieves superior segmentation accuracy, enabling comprehensive morphological analysis.

Mar 25, 2024 | onlinelibrary.wiley.com | Jie Zhao |Wei Zhuang |Boyang Sun |Hua Bai

INTRODUCTION The striking development of immunotherapy, especially immune checkpoint inhibitors (ICIs), has brought obvious curative effect and prolonged overall survival (OS) for advanced non-small cell lung cancer (NSCLC) while some patients do not obtain benefit from immunotherapy.1 In response to the urgent need for precision medicine, determination of an optimal biomarker to enrich beneficial population of immunotherapy is essential to enhance healthcare cost-effectiveness.2 Programmed...

Feb 20, 2024 | onlinelibrary.wiley.com | Yichi Zhang |Hua Bai |Chong Chen |Yongjian Zhou

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202313332-sup-0001-SuppMat.pdf1.3 MB Supporting Information References 1, , , , , , , , Science 2001, 294, 1488. 2, , , , , , Sci. Adv. 2017, 3, 1602429. 3, , , , Science 2004, 306, 1910. 4, , , , Appl. Phys. Lett. 2006, 88, 182509. 5, , , , , Nat. Phys. 2015, 11, 1022. 6, , , , , , , , , Nature 2018, 561, 222. 7, , , , , , , , , , , , , , Sci. Adv.

Feb 20, 2024 | pericles.pericles-prod.literatumonline.com | Yichi Zhang |Hua Bai |Chong Chen |Yongjian Zhou

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202313332-sup-0001-SuppMat.pdf1.3 MB Supporting Information References 1, , , , , , , , Science 2001, 294, 1488. 2, , , , , , Sci. Adv. 2017, 3, 1602429. 3, , , , Science 2004, 306, 1910. 4, , , , Appl. Phys. Lett. 2006, 88, 182509. 5, , , , , Nat. Phys. 2015, 11, 1022. 6, , , , , , , , , Nature 2018, 561, 222. 7, , , , , , , , , , , , , , Sci. Adv.

Jan 26, 2024 | science.org | Rui Peng |Yuriko N. Koyanagi |Clémentine Eva Philibert |Seunghyun Moon |Xizhi Fu |Yichi Zhang | +15 more

Research Article PHYSICS Lei Han https://orcid.org/0000-0001-6152-0307, Xizhi Fu, [...] , Rui Peng, Xingkai Cheng, [...] , Jiankun Dai, Liangyang Liu https://orcid.org/0000-0003-0943-5468, Yidian Li, Yichi Zhang, Wenxuan Zhu, [...] , Hua Bai https://orcid.org/0000-0002-4853-4349, Yongjian Zhou https://orcid.org/0000-0003-4275-8234, Shixuan Liang, Chong Chen, Qian Wang, Xianzhe Chen https://orcid.org/0000-0002-8079-8838, Luyi Yang https://orcid.org/0000-0001-6260-1395, Yang Zhang...