Hualiang Jiang

Jan 11, 2025 | nature.com | Yue Wu |Hao Zhang |Hualiang Jiang |Huiyong Yin |Weiping Zhang |Cheng Luo

AbstractReactive oxygen species exacerbate nonalcoholic steatohepatitis (NASH) by oxidizing macromolecules; yet how they promote NASH remains poorly understood. Here, we show that peroxidase activity of global hepatic peroxiredoxin (PRDX) is significantly decreased in NASH, and palmitic acid (PA) binds to PRDX1 and inhibits its peroxidase activity. Using three genetic models, we demonstrate that hepatic PRDX1 protects against NASH in male mice.