Huiyong Yin

Jan 11, 2025 | nature.com | Yue Wu |Hao Zhang |Hualiang Jiang |Huiyong Yin |Weiping Zhang |Cheng Luo

AbstractReactive oxygen species exacerbate nonalcoholic steatohepatitis (NASH) by oxidizing macromolecules; yet how they promote NASH remains poorly understood. Here, we show that peroxidase activity of global hepatic peroxiredoxin (PRDX) is significantly decreased in NASH, and palmitic acid (PA) binds to PRDX1 and inhibits its peroxidase activity. Using three genetic models, we demonstrate that hepatic PRDX1 protects against NASH in male mice.

Jul 1, 2023 | onlinelibrary.wiley.com | Ming Wang |Rui Li |Han Qi |Lingling Cui |Zhen Liu |Jie Lu | +9 more

Mar 21, 2023 | mdpi.com | Rui Li |Ningning Liang |Yongzhen Tao |Huiyong Yin

Abstract:Urate is one of the key metabolites of purine metabolism, and the overproduction of urate in the liver or decreased excretion in the kidney in humans may lead to elevated levels of urate in the circulation, termed hyperuricemia (HU). The formation of monosodium urate (MSU) crystals in the joint or surrounding tissues may trigger inflammatory responses and gout attacks, which is the most common inflammatory arthritis.