Huan-Xiang Zhou

Nov 12, 2024 | elifesciences.org | Souvik Dey |Huan-Xiang Zhou |Werner Treptow |Matt MacAinsh

eLife Assessment In this potentially important study, the authors conducted atomistic simulations to probe the salt-dependent phase separation of the low-complexity domain of hnRN-PA1 (A1-LCD). The authors have identified both direct and indirect mechanisms of salt modulation, provided explanations for four distinct classes of salt dependence, and proposed a model for predicting protein properties from amino acid composition.

Sep 23, 2024 | cell.com | Huan-Xiang Zhou

Keywords biomolecular condensates phase separation threshold concentration fusion speed interfacial tension viscosity amorphous dense liquid critical slowing down critical scaling intrinsically disordered proteins Introduction Biomolecular condensates are formed via phase separation that is driven by various types of intermolecular attraction, including charge-charge, cation-π, π-π, hydrophobic, and hydrogen-bonding interactions.1,2 Many studies of the phase separation of oppositely charged...

Sep 8, 2024 | biorxiv.org | Huan-Xiang Zhou

AbstractAlzheimer's disease (AD) is caused by the assembly of amyloid-beta (Aβ) peptides into oligomers and fibrils. Endogenous Aβ aggregation may be assisted by cell membranes, which can accelerate the nucleation step enormously, but knowledge of membrane-assisted aggregation is still very limited. Here we used extensive MD simulations to structurally and energetically characterize key intermediates along the membrane-assisted aggregation pathways of Aβ40.

Jun 10, 2024 | biorxiv.org | Matthew MacAinsh |Souvik Dey |Huan-Xiang Zhou

AbstractThe low-complexity domain of hnRNPA1 (A1-LCD) phase separates in a salt-dependent manner.

May 31, 2024 | biorxiv.org | Souvik Dey |Huan-Xiang Zhou |Matthew MacAinsh

AbstractThe low-complexity domain of hnRNPA1 (A1-LCD) phase separates in a salt-dependent manner.