Matt MacAinsh

Nov 12, 2024 | elifesciences.org | Souvik Dey |Huan-Xiang Zhou |Werner Treptow |Matt MacAinsh

eLife Assessment In this potentially important study, the authors conducted atomistic simulations to probe the salt-dependent phase separation of the low-complexity domain of hnRN-PA1 (A1-LCD). The authors have identified both direct and indirect mechanisms of salt modulation, provided explanations for four distinct classes of salt dependence, and proposed a model for predicting protein properties from amino acid composition.