Werner Treptow

1 week ago | dx.doi.org | José Fiorote |Joao Alves |João Alves |Werner Treptow

Amino acid contacts between proteins A and B are maintained over the course of evolution through compensatory mutations. (1) Over the years, extensive investigations have highlighted the relevance of coevolutionary signals for ab initio inference of protein partners based on primary sequence analysis.

Nov 12, 2024 | elifesciences.org | Souvik Dey |Huan-Xiang Zhou |Werner Treptow |Matt MacAinsh

eLife Assessment In this potentially important study, the authors conducted atomistic simulations to probe the salt-dependent phase separation of the low-complexity domain of hnRN-PA1 (A1-LCD). The authors have identified both direct and indirect mechanisms of salt modulation, provided explanations for four distinct classes of salt dependence, and proposed a model for predicting protein properties from amino acid composition.