Iker Núñez-Carpintero

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The PENGUIN approach to reconstruct protein interactions at enhancer-promoter regions and its application to prostate cancer - Nature Communications

Dec 6, 2023 | nature.com | François Serra |Iker Núñez-Carpintero |Stefano Gustincich |Alfonso Valencia |Matthew Freedman |Claudia Giambartolomei

AbstractWe introduce Promoter-Enhancer-Guided Interaction Networks (PENGUIN), a method for studying protein-protein interaction (PPI) networks within enhancer-promoter interactions. PENGUIN integrates H3K27ac-HiChIP data with tissue-specific PPIs to define enhancer-promoter PPI networks (EPINs). We validated PENGUIN using cancer (LNCaP) and benign (LHSAR) prostate cell lines.

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