IMIB-Pascual Parrilla

Jun 12, 2024 | thelancet.com | Carlos Bravo-Pérez |IMIB-Pascual Parrilla |Ana Blanco

Background Inferior vena cava agenesis (IVCA) is a rare anomaly predisposing affected people to lower-limb venous thrombosis with low frequency of pulmonary embolism. Antenatal thrombosis and inherited thrombophilia have been suggested as causes of IVCA. However, there is little evidence on the clinical course and management of this condition. We designed a patient registry to assess the thrombotic risk and features of IVCA.

Apr 4, 2023 | thelancet.com | Maria Lozano |IMIB-Pascual Parrilla

Primary immune thrombocytopenia is an autoimmune disease associated with a reduced peripheral blood platelet count and complex underlying pathophysiology. Since spleen tyrosine kinase (Syk) is crucial in Fcγ receptor-mediated platelet phagocytosis, it was postulated that inhibition of Syk could be used as a possible mechanism to ameliorate disease activity.