Carlos Bravo-Pérez

Nov 21, 2024 | nature.com | Carlos Bravo-Pérez |Yasuo Kubota |Simona Pagliuca |Danai Dima |Hetty Carraway |Valeria Visconte

AbstractPast studies described occasional patients with myeloid neoplasms (MN) and coexistent large granular lymphocytic leukemia (LGLL) or T-cell clonopathy of unknown significance (TCUS), which may represent expansion of myeloid clonal hematopoiesis (CH) as triggers or targets of clonal cytotoxic T cell reactions. We retrospectively analyzed 349 LGLL/TCUS patients, 672 MN patients, and 1443 CH individuals to establish the incidence, genetic landscape, and clinical phenotypes of CH in LGLL.

Jun 12, 2024 | thelancet.com | Carlos Bravo-Pérez |IMIB-Pascual Parrilla |Ana Blanco

Background Inferior vena cava agenesis (IVCA) is a rare anomaly predisposing affected people to lower-limb venous thrombosis with low frequency of pulmonary embolism. Antenatal thrombosis and inherited thrombophilia have been suggested as causes of IVCA. However, there is little evidence on the clinical course and management of this condition. We designed a patient registry to assess the thrombotic risk and features of IVCA.