Inês Carqueijeiro

Nov 23, 2023 | nature.com | Inês Carqueijeiro |Hans Jansen |Thu-Thuy T. Dang |Sarah O’Connor |Michael Jensen |Sébastien Besseau | +2 more

AbstractMonoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized metabolites mainly produced in Gentianales to cope with environmental challenges. Due to their pharmacological properties, the biosynthetic modalities of several MIA types have been elucidated but not that of the yohimbanes.

Sep 4, 2023 | biorxiv.org | Anuj Sharma |Pamela Cruz |Inês Carqueijeiro |Dikki Pedenla Bomzan

AbstractRho Of Plant (ROP) GTPases function as molecular switches that control signaling processes essential for growth, development, and defense. However, their role in specialized metabolism is poorly understood. Previously, we demonstrated that inhibition of protein geranylgeranyl transferase (PGGT-I) negatively impacts the biosynthesis of monoterpenoid indole alkaloids (MIA) in Catharanthus roseus, indicating the involvement of prenylated proteins in signaling.