Ingie Hong

Jan 14, 2025 | biorxiv.org | Julia Brill |Blaise Clarke |Ingie Hong |Richard Huganir

AbstractSYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intel-lectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signaling through its GAP enzymatic activity, SYNGAP1 plays an important structural role through its interaction with post-synaptic density proteins.

Oct 2, 2024 | nature.com | Ingie Hong |Thomas Hainmueller |Dong Won Kim |Richard Johnson |Nathachit Limjunyawong |David Cheon | +7 more

AbstractThe brain helps us survive by forming internal representations of the external world1,2. Excitatory cortical neurons are often precisely tuned to specific external stimuli3,4. However, inhibitory neurons, such as parvalbumin-positive (PV) interneurons, are generally less selective5. PV interneurons differ from excitatory neurons in their neurotransmitter receptor subtypes, including AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors (AMPARs)6,7.

Jul 20, 2023 | biorxiv.org | Ingie Hong |Juhyun Kim |Thomas Hainmueller |Dong Won Kim

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May 25, 2023 | biorxiv.org | Yoichi Araki |Kacey E. Rajkovich |Ingie Hong |Elizabeth E. Gerber

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