Julia Brill

Jan 14, 2025 | biorxiv.org | Julia Brill |Blaise Clarke |Ingie Hong |Richard Huganir

AbstractSYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intel-lectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signaling through its GAP enzymatic activity, SYNGAP1 plays an important structural role through its interaction with post-synaptic density proteins.

Nov 1, 2024 | eneuro.org | David Linden |Julia Brill

cognitiveestradiolletrozoleneurosteroidplasticitysynapsesSignificance StatementAromatase inhibitors are widely used drugs used to suppress estrogen biosynthesis in adjuvant therapy for estrogen receptor-positive breast cancer. This also reduces estrogen levels in the brain, where it normally functions as a neuromodulator. While successful in reducing cancer recurrence rates, it is associated with cognitive side effects, but it is unclear if there is a causal relation.