Richard Huganir

Jan 14, 2025 | biorxiv.org | Julia Brill |Blaise Clarke |Ingie Hong |Richard Huganir

AbstractSYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intel-lectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signaling through its GAP enzymatic activity, SYNGAP1 plays an important structural role through its interaction with post-synaptic density proteins.