Ingrid Kockum

Jan 11, 2024 | jnnp.bmj.com | Eva Johansson |Lars Alfredsson |Pernilla Strid |Ingrid Kockum

DiscussionWe observed an increased risk of developing MS following head trauma, particularly if the head trauma occurred within a 5-year time frame before disease onset. We also observed synergistic effects between head trauma and the main MS risk HLA alleles regarding the risk of developing the disease.

Jul 3, 2023 | nature.com | Asmundur Oddsson |Patrick Sulem |Gardar Sveinbjornsson |Gudny A. Arnadottir |Valgerdur Steinthorsdottir |Gísli H. Halldórsson | +41 more

Author notesThese authors contributed equally: Asmundur Oddsson, Patrick Sulem. These authors jointly supervised this work: Kari Stefansson, Daniel F. Gudbjartsson. Authors and AffiliationsdeCODE genetics/Amgen, Inc., Reykjavik, IcelandAsmundur Oddsson, Patrick Sulem, Gardar Sveinbjornsson, Gudny A. Arnadottir, Valgerdur Steinthorsdottir, Gisli H. Halldorsson, Bjarni A. Atlason, Gudjon R. Oskarsson, Hannes Helgason, Hildigunnur Katrinardottir, Run Fridriksdottir, Brynjar O.

Jun 10, 2023 | nature.com | Asmundur Oddsson |Patrick Sulem |Gardar Sveinbjornsson |Gudny A. Arnadottir |Valgerdur Steinthorsdottir |Gísli H. Halldórsson | +41 more

Study samples and ethics declarationsFor Iceland, this study is based on whole-genome sequence data from the white blood cells of 49,708 Icelanders participating in various disease projects at deCODE Genetics14. In addition, a total of 155,250 Icelanders have been genotyped using Illumina SNP chips. All participating individuals who donated blood or buccal tissue samples, or their guardians, provided written informed consent.