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Feb 27, 2025 | 
nature.com | Ida Erngren |Eva Freyhult |Yassine Noui |Ola Spjuth |Ingrid Kockum |Anna Karin Hedström | +2 more
AbstractExposure to per- and polyfluorinated substances (PFAS) and hydroxylated polychlorinated biphenyls (OH-PCBs) is associated with adverse human health effects, including immunosuppression. It is unknown if these substances can affect the course of autoimmune diseases. This study was based on 907 individuals with multiple sclerosis (MS) and 907 matched controls, where the MS cases were followed longitudinally using the Swedish MS register.
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May 23, 2024 | 
acrjournals.onlinelibrary.wiley.com | Anton Öberg Sysojev |Lars Alfredsson |Lars Klareskog |Gilad Silberberg
INTRODUCTION Patients with rheumatoid arthritis (RA) are at increased risk of various comorbid conditions.1-3 Of these, cardiovascular disease (CVD) is among the most prevalent, with studies suggesting a 50% increased risk of CVD incidence among patients with RA compared to the general population.4, 5 Although CVD risk factors are more prevalent among patients with RA than the general population, such factors do not alone explain the entirety of the excess risk,6, 7 leading researchers to...
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Mar 19, 2024 | 
neurologylive.com | Lars Alfredsson
WATCH TIME: 8 minutes“We believe obesity is related to the poorest progression in [multiple sclerosis] but we cannot stay that for those who are overweight.”Over the last decade, several global studies have demonstrated that early childhood and adolescent obesity are significant risk factors for multiple sclerosis (MS) susceptibility.
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Mar 5, 2024 | 
onlinelibrary.wiley.com | Jing Wu |Stockholm Sweden |Tomas Olsson |Lars Alfredsson
BACKGROUND Multiple sclerosis (MS) is a complex inflammatory and neurodegenerative disorder of the central nervous system, and its occurrence is positively associated with increasing latitude [1]. Insufficient sun exposure and vitamin D deficiency have consistently been associated with an increased risk of the disease [2, 3]. Higher latitude has also been associated with more severe disease [4, 5].
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Jan 11, 2024 | 
jnnp.bmj.com | Eva Johansson |Lars Alfredsson |Pernilla Strid |Ingrid Kockum
DiscussionWe observed an increased risk of developing MS following head trauma, particularly if the head trauma occurred within a 5-year time frame before disease onset. We also observed synergistic effects between head trauma and the main MS risk HLA alleles regarding the risk of developing the disease.
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Nov 21, 2023 | 
acrjournals.onlinelibrary.wiley.com | Lars Alfredsson |Lars Klareskog MD |Anna Karin Hedström
Disease activity and health-related quality of life among patients with rheumatoid arthritis with different alcohol consumption habits: additional comments Lars Alfredsson PhD, Lars Alfredsson PhD Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Search for more papers by this authorLars Klareskog MD, PhD, Lars Klareskog MD, PhD Department of Medicine, Rheumatology Unit, Karolinska Institutet at Karolinska University Hospital, Solna, Stockholm, Sweden Search for...
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Sep 22, 2023 | 
acrjournals.onlinelibrary.wiley.com | Lars Alfredsson |Lars Klareskog |Solna Sweden
To the Editor: We are grateful for the constructive engagement with our article from Xie et al,1 Lin et al,2 and Wang et al3 and have the following comments to their questions and concerns. Xie et al raise concerns regarding the potential influence of drug use on our study results.1 We examined this aspect by adjusting for treatment categorized into groups of specific disease-modifying antirheumatic drugs, which yielded results similar to our dichotomous categorization.
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Jul 3, 2023 | 
nature.com | Asmundur Oddsson |Patrick Sulem |Gardar Sveinbjornsson |Gudny A. Arnadottir |Valgerdur Steinthorsdottir |Gísli H. Halldórsson | +41 more
Author notesThese authors contributed equally: Asmundur Oddsson, Patrick Sulem. These authors jointly supervised this work: Kari Stefansson, Daniel F. Gudbjartsson. Authors and AffiliationsdeCODE genetics/Amgen, Inc., Reykjavik, IcelandAsmundur Oddsson, Patrick Sulem, Gardar Sveinbjornsson, Gudny A. Arnadottir, Valgerdur Steinthorsdottir, Gisli H. Halldorsson, Bjarni A. Atlason, Gudjon R. Oskarsson, Hannes Helgason, Hildigunnur Katrinardottir, Run Fridriksdottir, Brynjar O.
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Jun 27, 2023 | 
journals.sagepub.com | Lars Alfredsson |Tomas Olsson |Anna Karin Hedström
AbstractObjective:There is some evidence implicating diet in the development of inflammatory diseases. We aimed to study the influence of dietary habits on the risk of developing multiple sclerosis (MS). Methods:We used a population-based case–control study recruiting incident cases of MS (1953 cases, 3557 controls).
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Jun 10, 2023 | 
nature.com | Asmundur Oddsson |Patrick Sulem |Gardar Sveinbjornsson |Gudny A. Arnadottir |Valgerdur Steinthorsdottir |Gísli H. Halldórsson | +41 more
Study samples and ethics declarationsFor Iceland, this study is based on whole-genome sequence data from the white blood cells of 49,708 Icelanders participating in various disease projects at deCODE Genetics14. In addition, a total of 155,250 Icelanders have been genotyped using Illumina SNP chips. All participating individuals who donated blood or buccal tissue samples, or their guardians, provided written informed consent.
