Ioannis Ntekas

Nov 21, 2024 | nature.com | Lauren Walter |Ioannis Ntekas |Viviana I Maymi |Brian Rudd |Iwijn De Vlaminck |Jennifer H. Elisseeff

AbstractIn aging, skeletal muscle regeneration declines due to alterations in both myogenic and non-myogenic cells and their interactions. This regenerative dysfunction is not understood comprehensively or with high spatiotemporal resolution. We collected an integrated atlas of 273,923 single-cell transcriptomes and high-resolution spatial transcriptomic maps from muscles of young, old and geriatric mice (~5, 20 and 26 months old) at multiple time points following myotoxin injury.