Jennifer H. Elisseeff

Nov 21, 2024 | nature.com | Lauren Walter |Ioannis Ntekas |Viviana I Maymi |Brian Rudd |Iwijn De Vlaminck |Jennifer H. Elisseeff

AbstractIn aging, skeletal muscle regeneration declines due to alterations in both myogenic and non-myogenic cells and their interactions. This regenerative dysfunction is not understood comprehensively or with high spatiotemporal resolution. We collected an integrated atlas of 273,923 single-cell transcriptomes and high-resolution spatial transcriptomic maps from muscles of young, old and geriatric mice (~5, 20 and 26 months old) at multiple time points following myotoxin injury.

Feb 28, 2024 | pericles.pericles-prod.literatumonline.com | Jin H. Han |Alexandra Rindone |Jennifer H. Elisseeff

Corresponding Author Jennifer H.

Dec 18, 2023 | nature.com | Kavita Krishnan |Jennifer H. Elisseeff

AbstractRegenerative medicine and tissue engineering aim to promote functional rebuilding of damaged tissue. Comprehensively profiling cell identity, function and interaction in healthy tissues, as well as understanding how these change upon tissue disruption, such as that caused by injury, ageing or infection, is foundational to advancing tissue engineering and regenerative therapeutics.