Iwijn De Vlaminck

Dec 12, 2024 | onlinecjc.ca | Conor J Loy |Hao Wang |Jihoon Kim |Chisato Shimizu |Adriana H. Tremoulet |Jane Burns | +1 more

Kawasaki Disease (KD) presents with diverse manifestations and outcomes. Recent work by Wang et al. identified four distinct KD subgroups based on clinical and laboratory features: elevated liver involvement (subgroup 1: liver), high band neutrophil counts (subgroup 2: band), prominent cervical lymphadenopathy (subgroup 3: node), and younger age (subgroup 4: young). Plasma cell-free RNA (cfRNA), released by circulating and solid tissue cells, offers insight into systemic cellular dynamics.

Nov 21, 2024 | nature.com | Lauren Walter |Ioannis Ntekas |Viviana I Maymi |Brian Rudd |Iwijn De Vlaminck |Jennifer H. Elisseeff

AbstractIn aging, skeletal muscle regeneration declines due to alterations in both myogenic and non-myogenic cells and their interactions. This regenerative dysfunction is not understood comprehensively or with high spatiotemporal resolution. We collected an integrated atlas of 273,923 single-cell transcriptomes and high-resolution spatial transcriptomic maps from muscles of young, old and geriatric mice (~5, 20 and 26 months old) at multiple time points following myotoxin injury.

Jun 11, 2024 | nature.com | Eliah G. Overbey |JangKeun Kim |Braden T. Tierney |Jiwoon Park |Deena Najjar |Remi Klotz | +30 more

AbstractSpaceflight induces molecular, cellular, and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1-6. Yet, current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools, and protocols.

Jun 11, 2024 | nature.com | Christopher Mason |James Green |Jordan Baechle |Mathias Basner |Susan Bailey |Joseph Borg | +34 more

AbstractThe recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a ‘second space age’.

Jun 10, 2024 | nature.com | JangKeun Kim |Braden T. Tierney |Eliah G. Overbey |Ezequiel Dantas |Jiwoon Park |Fei Wu | +16 more

AbstractSpaceflight induces an immune response in astronauts. To better characterize this effect, we generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data for the SpaceX Inspiration4 (I4) mission crew. We found that 18 cytokines/chemokines related to inflammation, aging, and muscle homeostasis changed after spaceflight.