Ioannis Pittarokoilis

Mar 27, 2024 | nature.com | Vanessa Monteil |Shane Wright |Sofia Appelberg |Hyesoo Kwon |Ioannis Pittarokoilis |Georg Michlits | +11 more

AbstractClimate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean–Congo haemorrhagic fever virus (CCHFV). Here we report that the Low Density Lipoprotein Receptor (LDLR) is a critical receptor for CCHFV cell entry, playing a vital role in CCHFV infection in cell culture and blood vessel organoids.