Georg Michlits

Mar 27, 2024 | nature.com | Vanessa Monteil |Shane Wright |Sofia Appelberg |Hyesoo Kwon |Ioannis Pittarokoilis |Georg Michlits | +11 more

AbstractClimate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean–Congo haemorrhagic fever virus (CCHFV). Here we report that the Low Density Lipoprotein Receptor (LDLR) is a critical receptor for CCHFV cell entry, playing a vital role in CCHFV infection in cell culture and blood vessel organoids.

Oct 25, 2023 | nature.com | Vanessa Monteil |Hyesoo Kwon |Cristiano Salata |Gustav Jönsson |Sofia Appelberg |Astrid Hagelkrüys | +7 more

AbstractMarburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify the guanine nucleotide exchange factor CCZ1 as a key host factor in the early stage of filovirus replication.