Shane Wright

Jun 18, 2024 | science.org | Shane Wright |Kun Ping Lu |Wei Wong |Xiao Zhou

AbstractProtein phosphorylation is one of the most common mechanisms regulating cellular signaling pathways, and many kinases and phosphatases are proven drug targets. Upon phosphorylation, protein functions can be further regulated by the distinct isomerase Pin1 through cis-trans isomerization. Numerous protein targets and many important roles have now been elucidated for Pin1. However, no tools are available to detect or target cis and trans conformation events in cells.

Jun 18, 2024 | science.org | Shane Wright |Kun Ping Lu |Wei Wong

AbstractSuppression of GLP-1 release by a gut microbiota–derived metabolite induces polycystic ovary syndrome. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Polycystic ovary syndrome (PCOS) is an endocrine disorder that is characterized by hormonal imbalances, including hyperandrogenism, and that results in infertility and cardiovascular and metabolic abnormalities in women.

Mar 27, 2024 | nature.com | Vanessa Monteil |Shane Wright |Sofia Appelberg |Hyesoo Kwon |Ioannis Pittarokoilis |Georg Michlits | +11 more

AbstractClimate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean–Congo haemorrhagic fever virus (CCHFV). Here we report that the Low Density Lipoprotein Receptor (LDLR) is a critical receptor for CCHFV cell entry, playing a vital role in CCHFV infection in cell culture and blood vessel organoids.