Irene Perini

Feb 25, 2024 | nature.com | Adam Yngve |J. Paul Hamilton |Emil Persson |Andrea J. Capusan |Lorenzo Leggio |Irene Perini | +1 more

AbstractThe stomach-derived hormone ghrelin plays not only a role in feeding, starvation, and survival, but it has been suggested to also be involved in the stress response, in neuropsychiatric conditions, and in alcohol and drug use disorders. Mechanisms related to reward processing might mediate ghrelin’s broader effects on complex behaviors, as indicated by animal studies and mostly correlative human studies.

Jan 30, 2024 | biorxiv.org | Saptarnab Naskar |Leah M. Mayo |Irene Perini |Luis E. Rosas-Vidal

AbstractMaladaptive fear generalization is one of the hallmarks of trauma-related disorders. The endocannabinoid 2-arachidonoylglycerol (2-AG) is crucial for modulating anxiety, fear, and stress adaptation but its role in balancing fear discrimination versus generalization is not known.

Dec 12, 2023 | onlinelibrary.wiley.com | Mohamed Selim |Maayan Harel |Silvia De Santis |Irene Perini

Among the population aged 15–49 years, alcohol consumption is the leading risk factor for both deaths and disability-adjusted life-years, with 3.8% of female deaths and 12.2% of male deaths attributable to alcohol use, according to recent data.1 Alcohol use disorder (AUD), the chronic excessive consumption of alcohol, is a chronic illness characterized by cycles of relapse and remission, with several associated co-morbidities and complex neurobiological substrates of alterations.