Lorenzo Leggio
Editor in Chief at Alcohol and Alcoholism
Physician-scientist, translational and clinical addiction researcher, music junkie, lucky husband, he/him. This is my personal account. These views are my own.
Articles
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1 month ago |
nature.com | Lorenzo Leggio
Despite significant developments in basic neuroscience and pharmacology of alcohol use disorder (AUD), no new medications have been approved for AUD in the past two decades. While there is no single reason for what is often referred to as the ‘valley of death’ in medication development, this challenge requires novel, creative approaches.
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Oct 8, 2024 |
onlinelibrary.wiley.com | Neda Seyedsadjadi |Lorenzo Leggio |Mariel Molina-Castro |Danisa Nieto
1 INTRODUCTION There is a growing interest in innovative approaches to treating alcohol use disorder (AUD), including a recent focus on gut-brain peptides that regulate both homeostatic hunger and reward processing and motivation for food-seeking.1-4 One such peptide is glucagon-like peptide-1 (GLP-1), an anorectic incretin hormone derived from intestinal preproglucagon-containing cells and neurons in the nucleus tractus solitarii.5 Indeed, GLP-1 receptor agonists are among the most...
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Sep 11, 2024 |
mdedge.com | AKSHAY JAIN |Lorenzo Leggio
This transcript has been edited for clarity. Akshay B. Jain, MD: Today we are very excited to have Dr. Leggio join us all the way from the National Institutes of Health (NIH). He is an addiction physician scientist in the intramural research program at NIH. Welcome, Dr. Leggio. Thanks for joining us. Lorenzo Leggio, MD, PhD: Thank you so much. Dr. Jain: We’ll get right into this. Your session was, in my mind, extremely informative.
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Jun 3, 2024 |
jci.org | Markus Heilig |Katie Witkiewitz |Lara A Ray |Lorenzo Leggio
AbstractAlcohol-related harm, a major cause of disease burden globally, affects people along a spectrum of use. When a harmful pattern of drinking is present in the absence of significant behavioral pathology, low-intensity brief interventions that provide information about health consequences of continued use provide large health benefits.
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Feb 25, 2024 |
nature.com | Adam Yngve |J. Paul Hamilton |Emil Persson |Andrea J. Capusan |Lorenzo Leggio |Irene Perini | +1 more
AbstractThe stomach-derived hormone ghrelin plays not only a role in feeding, starvation, and survival, but it has been suggested to also be involved in the stress response, in neuropsychiatric conditions, and in alcohol and drug use disorders. Mechanisms related to reward processing might mediate ghrelin’s broader effects on complex behaviors, as indicated by animal studies and mostly correlative human studies.
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RT @NIDAnews: Interested in learning more about research at NIDA in Baltimore, MD? NIDA welcomes participants to join our ongoing research…
RT @NIAAAnews: Findings by #NIH/#NIAAA researchers led by Dr. Lorenzo Leggio suggest GLP-1R agonists can be effective to reduce AUDIT-C sco…
RT @MehdiFarokhnia: 🚨 Glucagon-like peptide-1 receptor agonists but not dipeptidyl peptidase-4 inhibitors reduce alcohol intake. Super pro…