Lorenzo Leggio

3 weeks ago | thelancet.com | Ashwani Singal |Louisville KY |Lorenzo Leggio |Clinical Psychoneuroendocrinology

aDepartment of Medicine, Division of GI Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY 40202, USA bJewish Hospital and Trager Transplant Center, Louisville KY, USA cRob Rexley Veterans Affairs Medical Center, Louisville, KY, USA dClinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism...

Mar 19, 2025 | nature.com | Lorenzo Leggio

Despite significant developments in basic neuroscience and pharmacology of alcohol use disorder (AUD), no new medications have been approved for AUD in the past two decades. While there is no single reason for what is often referred to as the ‘valley of death’ in medication development, this challenge requires novel, creative approaches.

Oct 8, 2024 | onlinelibrary.wiley.com | Neda Seyedsadjadi |Lorenzo Leggio |Mariel Molina-Castro |Danisa Nieto

1 INTRODUCTION There is a growing interest in innovative approaches to treating alcohol use disorder (AUD), including a recent focus on gut-brain peptides that regulate both homeostatic hunger and reward processing and motivation for food-seeking.1-4 One such peptide is glucagon-like peptide-1 (GLP-1), an anorectic incretin hormone derived from intestinal preproglucagon-containing cells and neurons in the nucleus tractus solitarii.5 Indeed, GLP-1 receptor agonists are among the most...

Sep 11, 2024 | mdedge.com | AKSHAY JAIN |Lorenzo Leggio

This transcript has been edited for clarity. Akshay B. Jain, MD: Today we are very excited to have Dr. Leggio join us all the way from the National Institutes of Health (NIH). He is an addiction physician scientist in the intramural research program at NIH. Welcome, Dr. Leggio. Thanks for joining us. Lorenzo Leggio, MD, PhD: Thank you so much. Dr. Jain: We’ll get right into this. Your session was, in my mind, extremely informative.

Jun 3, 2024 | jci.org | Markus Heilig |Katie Witkiewitz |Lara A Ray |Lorenzo Leggio

AbstractAlcohol-related harm, a major cause of disease burden globally, affects people along a spectrum of use. When a harmful pattern of drinking is present in the absence of significant behavioral pathology, low-intensity brief interventions that provide information about health consequences of continued use provide large health benefits.