Isaac Fianu

Apr 3, 2024 | nature.com | Isaac Fianu |Moritz Ochmann |James Walshe |Olexandr Dybkov |Henning Urlaub

AbstractThe Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal region of genes. Previous work has shed light on how Integrator binds to the paused elongation complex consisting of Pol II, the DRB sensitivity-inducing factor (DSIF) and the negative elongation factor (NELF) and how it cleaves the nascent RNA transcript1, but has not explained how Integrator removes Pol II from the DNA template.