Isabel Mendizabal

Jun 3, 2024 | biorxiv.org | Hyeonsoo Jeong |Isabel Mendizabal |Soojin V. Yi |Basque Research

AbstractSignificant links between aging and DNA methylation are emerging from recent studies. On the one hand, DNA methylation undergoes changes with age, a process termed as epigenetic drift. On the other hand, DNA methylation serves as a readily accessible and accurate biomarker for aging. A key missing piece of information, however, is the molecular mechanisms underlying these processes, and how they are related, if any.

Apr 17, 2024 | biorxiv.org | Devika Singh |Isabel Mendizabal |Eddie Loh

AbstractThe mechanisms of X chromosome inactivation suggest fundamental epigenetic differences between the female and male X chromosomes. However, DNA methylation studies often exclude the X chromosomes. In addition, many previous studies relied on techniques that examine non-randomly selected subsets of positions such as array-based methods, rather than assessing the whole X chromosome. Consequently, our understanding of X chromosome DNA methylation lags behind that of autosomes.