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Sep 18, 2024 | 
nature.com | Miklos Diossy |Pranshu Sahgal |Judit Börcsök |Dávid Szüts |Alan D. D’Andrea |István Csabai | +2 more
AbstractWe analyzed genomic data from the prostate cancer of African- and European American men to identify differences contributing to racial disparity of outcome. We also performed FISH-based studies of Chromodomain helicase DNA-binding protein 1 (CHD1) loss on prostate cancer tissue microarrays. We created CHD1-deficient prostate cancer cell lines for genomic, drug sensitivity and functional homologous recombination (HR) activity analysis.
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May 17, 2024 | 
biorxiv.org | Norbert Solymosi |Adrienn Gréta Tóth |Sara Nagy |István Csabai
AbstractAntimicrobial resistance (AMR) is one of our greatest public health challenges. Targeted use of antibiotics (AB) can reduce the occurrence and spread of AMR and boost the effectiveness of treatment. This requires knowledge of the antibiotic susceptibility (AS) of the pathogens involved in the disease. Therapeutic recommendations based on classical antibiotic susceptibility testing (AST) are based on the analysis of only a fraction of the bacteria present in the disease process.
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Apr 7, 2024 | 
nature.com | Pranshu Sahgal |Brandon Huffman |Judit Börcsök |István Csabai |Michael Cecchini
AbstractHomologous recombination (HR) and nucleotide excision repair (NER) are the two most frequently disabled DNA repair pathways in cancer. HR-deficient breast, ovarian, pancreatic and prostate cancers respond well to platinum chemotherapy and PARP inhibitors. However, the frequency of HR deficiency in gastric and esophageal adenocarcinoma (GEA) still lacks diagnostic and functional validation.
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Jan 15, 2024 | 
nature.com | István Csabai
AbstractAgeing is often characterised by progressive accumulation of damage, and it is one of the most important risk factors for chronic disease development. Epigenetic mechanisms including DNA methylation could functionally contribute to organismal aging, however the key functions and biological processes may govern ageing are still not understood.
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Oct 19, 2023 | 
nature.com | Sándor Spisák |Bálint Ármin Pataki |Dezso Ribli |Connor Bell |Mersedeh Rohanizadegan |Sarah Abou Alaiwi | +8 more
Correction to: Nature Communications https://doi.org/10.1038/s41467-023-40616-z, published online 23 Aug 2023In this article, the author’s name Alan H. Bartels was incorrectly written as Alan B. Bartels. The original article has been corrected.
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Aug 23, 2023 | 
nature.com | Sándor Spisák |Bálint Ármin Pataki |Connor Bell |Sarah Abou Alaiwi |Márton Papp |Xianzhi Lin | +8 more
AbstractTo date, single-nucleotide polymorphisms (SNPs) have been the most intensively investigated class of polymorphisms in genome wide associations studies (GWAS), however, other classes such as insertion-deletion or multiple nucleotide length polymorphism (MNLPs) may also confer disease risk. Multiple reports have shown that the 5p15.33 prostate cancer risk region is a particularly strong expression quantitative trait locus (eQTL) for Iroquois Homeobox 4 (IRX4) transcripts.
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Aug 4, 2023 | 
biorxiv.org | István Csabai |Norbert Solymosi |Eötvös Loránd |Regina Nora Fiam
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Jul 28, 2023 | 
nature.com | László Makrai |Sara Nagy |István Csabai |Bettina Fodróczy |Péter Czeiszing
AbstractQuantifying bacteria per unit mass or volume is a common task in various fields of microbiology (e.g., infectiology and food hygiene). Most bacteria can be grown on culture media. The unicellular bacteria reproduce by dividing into two cells, which increases the number of bacteria in the population. Methodologically, this can be followed by culture procedures, which mostly involve determining the number of bacterial colonies on the solid culture media that are visible to the naked eye.
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Apr 29, 2023 | 
biorxiv.org | Sara Nagy |László Makrai |István Csabai |Géza Szita
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Mar 14, 2023 | 
nature.com | Oz Kilim |István Csabai |Anikó Mentes |Balázs Pál
AbstractLeveraging recent advances in computational modeling of proteins with AlphaFold2 (AF2) we provide a complete curated data set of all single mutations from each of the 7 main SARS-CoV-2 lineages spike protein receptor binding domain (RBD) resulting in 3819X7 = 26733 PDB structures. We visualize the generated structures and show that AF2 pLDDT values are correlated with state-of-the-art disorder approximations, implying some internal protein dynamics are also captured by the model.
