Ivana Geric

Mar 27, 2024 | nature.com | Renzo Mancuso |Anna Martinez-Muriana |Emma Davis |Ivana Geric |Baukje Bijnens |Catherine Verfaillie

AbstractMicroglia are central players in Alzheimer’s disease pathology but analyzing microglial states in human brain samples is challenging due to genetic diversity, postmortem delay and admixture of pathologies. To circumvent these issues, here we generated 138,577 single-cell expression profiles of human stem cell-derived microglia xenotransplanted in the brain of the AppNL-G-F model of amyloid pathology and wild-type controls.