Anna Martinez-Muriana

May 16, 2024 | biorxiv.org | Amy Lloyd |Anna Martinez-Muriana |Emma Davis |Michael Daniels

AbstractUsing high resolution quantitative mass spectrometry, we have generated the most comprehensive human and mouse microglia proteomic datasets to date, consisting of over 11,000 proteins across all six microglia groups. Microglia from different sources share a core protein signature of over 5600 proteins, yet fundamental differences are observed between species and culture conditions, indicating limitations for human disease modelling in mouse or in in vitro cultures of microglia.

Mar 27, 2024 | nature.com | Renzo Mancuso |Anna Martinez-Muriana |Emma Davis |Ivana Geric |Baukje Bijnens |Catherine Verfaillie

AbstractMicroglia are central players in Alzheimer’s disease pathology but analyzing microglial states in human brain samples is challenging due to genetic diversity, postmortem delay and admixture of pathologies. To circumvent these issues, here we generated 138,577 single-cell expression profiles of human stem cell-derived microglia xenotransplanted in the brain of the AppNL-G-F model of amyloid pathology and wild-type controls.