J. Parker

Oct 8, 2024 | onlinecjc.ca | S. Dababneh |J. Parker |R. Ahmed |D. Comber |J. Phulka |C. Tsai | +4 more

The development of atrial fibrillation (AF) in patients with non-ischemic cardiomyopathy (NICM), a precursor for heart failure with prominent genetic underpinnings, is associated with poor prognosis. Tools to risk stratify NICM patients for AF remain lacking. With the rise of scientific advancements enabling personalized risk stratification, such as polygenic risk scores and serum proteomics, we sought to employ a proteogenomics approach to improve prediction of AF in patients with NICM.

Oct 8, 2024 | onlinecjc.ca | S. Safabakhsh |R. Pancaroglu |D. S. Dissanayake |J. Parker |S. Barichello |P. Panwar | +4 more

Atrial fibrillation (AF) is the most common sustained arrhythmia. Currently, there are no biomarkers available for monitoring AF progression or for serving as targets for disease-modifying therapies. Research in this area is increasingly pointing to a role for post-translational phosphorylation of cardiac ryanodine receptor 2 (RyR2) as a promising avenue for biomarker discovery. Most studies of RyR2 phosphorylation in AF have focused on single phosphorylation sites using antibody-based assays.

Sep 30, 2024 | statnews.com | Bob Herman |J. Parker |Lizzy Lawrence |Tara Bannow |Mohana Ravindranath

Average CEO pay in health care was $11 million last year. Moderna's Stéphane Bancel, at $305 million, leads STAT's annual executive compensation survey.

Jul 6, 2024 | sciencedirect.com | J. Parker |X. Chen |Qinli Pu |Guoming Xie

In living cells, thousands of miRNAs have been discovered, all of which play important roles in vital biological events such as cell growth, proliferation, and apoptosis [1], [2]. Part of miRNA expression variation can serve as a rich source for biomarker discovery in disease diagnosis, treatment, and biomedical engineering [3], [4], [5], [6], [7].

May 7, 2024 | tandfonline.com | J. Parker |K. R. Griffiths |M. A. Bennett |D. L. Dunning

?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. ABSTRACTSustained attention, a key cognitive skill that improves during childhood and adolescence, tends to be worse in some emotional and behavioural disorders.