Jacob Bledsoe

Aug 16, 2024 | jcp.bmj.com | Xenia Parisi |Jacob Bledsoe

General conceptsNeutropenia is generally defined as an absolute neutrophil count (ANC) <1500 cells/µL in adults and children over 1 year of age, but thresholds vary by age and ethnicity.7 8 The risk for infection correlates inversely with ANC. Severe neutropenia, an ANC<500 cells/µL, is associated with a high risk of overwhelming bacterial infection and mortality, even if optimally managed.

Apr 8, 2024 | jcp.bmj.com | Xenia Parisi |Jacob Bledsoe

Handling editor Vikram Deshpande. X @XeniaParisiContributors XP and JRB both contributed significantly to the conceptualisation and writing of this manuscript. Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors. Competing interests JRB serves as a consultant for X4 Pharmaceuticals and has a research agreement with X4 Pharmaceutical on flow cytometric features of neutropenia syndromes.

Dec 27, 2023 | mdpi.com | Marcos Marcondes Godoy |Jacob Bledsoe |Yoandy Coca |Rudy Suárez

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Nov 22, 2023 | onlinelibrary.wiley.com | Franziska Wachter |Yana Pikman |Jacob Bledsoe |Malika Kapadia

1 INTRODUCTION Survival is dismal for the 40%–60% of children with myelodysplastic syndrome (MDS) who relapse post allogeneic hematopoietic cell transplantation (HCT).1-3 Strategies to decrease relapse risk includes use of cytoreduction prior to HCT or maintenance treatment after HCT, data on the utility of these approaches remains limited.4-12 Rapid withdrawal of immune suppression or use of donor lymphocyte infusion (DLI) can enhance the graft versus leukemia effect and achieve disease...

May 7, 2023 | pubmed.ncbi.nlm.nih.gov | Jacob Bledsoe |Bledsoe JR

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