Jake A. Lacey

Apr 24, 2024 | nature.com | Ouli Xie |Cameron Zachreson |David Price |Jake A. Lacey |Jacqueline Morris |Asha C Bowen | +4 more

AbstractStreptococcus dysgalactiae subspecies equisimilis (SDSE) and Streptococcus pyogenes share skin and throat niches with extensive genomic homology and horizontal gene transfer (HGT) possibly underlying shared disease phenotypes. It is unknown if cross-species transmission interaction occurs. Here, we conduct a genomic analysis of a longitudinal household survey in remote Australian First Nations communities for patterns of cross-species transmission interaction and HGT.

Mar 12, 2024 | nature.com | Ouli Xie |Jacqueline Morris |Andrew Hayes |Magnus G. Jespersen |John Lees |Sarah L. Baines | +8 more

AbstractStreptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic genomic analyses of 501 disseminated SDSE strains, we demonstrate extensive overlap between the genomes of SDSE and S. pyogenes.

Feb 24, 2023 | nature.com | Mark Davies |Stephan Brouwer |Magnus G. Jespersen |Amanda J. Cork |Andrew Hayes |Miranda Pitt | +7 more

AbstractA new variant of Streptococcus pyogenes serotype M1 (designated ‘M1UK’) has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen SpeA. The progenitor S. pyogenes ‘M1global’ and M1UK clones can be differentiated by 27 SNPs and 4 indels, yet the mechanism for speA upregulation is unknown.