Jakub Kopal

Jan 14, 2025 | biorxiv.org | Jakub Kopal |Alexey Shadrin |Julian Führer |Jaroslav Rokicki

AbstractBackground: Metabolic processes form the basis of the development, functioning and maintenance of the brain. Despite accumulating evidence of the vital role of metabolism in brain health, no study to date has comprehensively investigated the link between circulating markers of metabolic activity and in vivo brain morphology in the general population.

Apr 10, 2024 | nature.com | Jakub Kopal |Karin Saltoun |Claudia Modenato |Guillaume Huguet |Zohra Saci |Elise Douard | +9 more

Correction to: Nature Communications https://doi.org/10.1038/s41467-024-46784-w, published online 26 March 2024In this article the affiliation details for Robert Zatorre were incorrectly given as ‘Department of Pediatrics, University of Montréal, Montréal, Quebec, Canada.’ but should have been ‘TheNeuro - Montreal Neurological Institute (MNI), McConnell Brain Imaging Centre, Faculty of Medicine, McGill University, Montreal, QC, Canada’. The original article has been corrected.

Mar 26, 2024 | nature.com | Jakub Kopal |Karin Saltoun |Claudia Modenato |Guillaume Huguet |Zohra Saci |Elise Douard | +9 more

AbstractAsymmetry between the left and right hemisphere is a key feature of brain organization. Hemispheric functional specialization underlies some of the most advanced human-defining cognitive operations, such as articulated language, perspective taking, or rapid detection of facial cues. Yet, genetic investigations into brain asymmetry have mostly relied on common variants, which typically exert small effects on brain-related phenotypes.

Mar 2, 2023 | nature.com | Jakub Kopal |Karin Saltoun |Guillaume Huguet |Martineau Jean-Louis |Zohra Saci |Elise Douard | +7 more

AbstractCopy number variations (CNVs) are rare genomic deletions and duplications that can affect brain and behaviour. Previous reports of CNV pleiotropy imply that they converge on shared mechanisms at some level of pathway cascades, from genes to large-scale neural circuits to the phenome. However, existing studies have primarily examined single CNV loci in small clinical cohorts.