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Jan 7, 2025 | 
nature.com | Romain Icick |Oleksandr Frei |Hang Zhou |Howard J. Edenberg |Joel Gelernter |Olav B. Smeland
AbstractAlcohol use disorder (AUD) is highly heritable and burdensome worldwide. Genome-wide association studies can provide new evidence regarding the etiology of AUD. We report a multi-ancestry genome-wide association study focusing on a narrow AUD phenotype, using novel statistical tools in a total sample of 1,041,450 individuals (102,079 cases; European, 75,583; African, 20,689 (mostly African American); Hispanic American, 3,449; East Asian, 2,254; South Asian, 104; descent).
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Oct 1, 2024 | 
nature.com | Shahram Bahrami |Kaja Nordengen |Olav B. Smeland |Nadine Staples Parker |Pravesh Parekh |Torbjørn Elvsåshagen | +4 more
AbstractThe basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ganglia volumes using brain scans obtained from 34,794 Europeans with replication in 4,808 white and generalization in 5,220 non-white Europeans.
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Aug 21, 2024 | 
nature.com | Milin Kim |Esten Leonardsen |Geir Selbæk |Nils Eiel Steen |Olav B. Smeland |Geneviève Richard | +4 more
AbstractThe cerebellum is linked to motor coordination, cognitive and affective processing, in addition to a wide range of clinical illnesses. To enable robust quantification of individual cerebellar anatomy relative to population norms, we mapped the normative development and aging of the cerebellum across the lifespan using brain scans of >54,000 participants. We estimated normative models at voxel-wise spatial precision, enabling integration with cerebellar atlases.
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Jun 3, 2024 | 
nature.com | Oleksandr Frei |Guy Hindley |Espen Hagen |Nadine Staples Parker |Olav B. Smeland |Christiaan de Leeuw | +2 more
AbstractWhile genome-wide association studies are increasingly successful in discovering genomic loci associated with complex human traits and disorders, the biological interpretation of these findings remains challenging.
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Jan 5, 2024 | 
nature.com | Elise Koch |Nils Eiel Steen |Olav B. Smeland |Srdjan Djurovic |Espen Molden
AbstractGenomic prediction of antipsychotic dose and polypharmacy has been difficult, mainly due to limited access to large cohorts with genetic and drug prescription data.
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Dec 3, 2023 | 
sciencedirect.com | Børge Holen |Olav B. Smeland |Mats Hallgren
Consumption of alkaline electrolyzed water (AEW) has become increasingly popular for consumer use. Although these alkaline water products are now commonly used, they are of questionable health benefit. Some individuals believe that it may help their dyspepsia. Furthermore, there is a paucity of evidence on its toxicologic profile and adverse effects.
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Sep 27, 2023 | 
ajp.psychiatryonline.org | Linn Rødevand |Zillur Rahman |Guy Hindley |Olav B. Smeland
Schizophrenia is associated with a two- to threefold greater risk of cardiovascular disease (CVD) compared with risk in the general population, contributing to a 10- to 20-year reduced life expectancy (1, 2). Despite increasing awareness of this comorbidity over recent decades, the level of CVD risk does not appear to have decreased for individuals with schizophrenia (3), and there has been little or no progress in decreasing the mortality gap (2, 4, 5).
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Sep 27, 2023 | 
nature.com | Nadine Staples Parker |Pravesh Parekh |Ivan Maximov |Olav B. Smeland |Srdjan Djurovic |Anders M. Dale | +2 more
AbstractImproved understanding of the shared genetic architecture between psychiatric disorders and brain white matter may provide mechanistic insights for observed phenotypic associations. Our objective is to characterize the shared genetic architecture of bipolar disorder (BD), major depression (MD), and schizophrenia (SZ) with white matter fractional anisotropy (FA) and identify shared genetic loci to uncover biological underpinnings.
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Sep 1, 2023 | 
nature.com | Shahram Bahrami |Guy Hindley |Olav B. Smeland |Oleksandr Frei |Chun C. Fan |Srdjan Djurovic | +2 more
AbstractAnorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric disorders and related traits have been reported, their shared genetic architecture is largely understudied.
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Jun 26, 2023 | 
nature.com | Guy Hindley |Alexey Shadrin |Shahram Bahrami |Børge Holen |Thomas Bjella |Gail Davies | +5 more
Author notesThese authors contributed equally: Guy Hindley, Alexey A. Shadrin. Authors and AffiliationsNORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NorwayGuy Hindley, Alexey A. Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin S. O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Børge Holen, Thomas Bjella, Torill Ueland, Olav B. Smeland, Oleksandr Frei & Ole A.
