James A. Blumenthal

May 7, 2024 | onlinelibrary.wiley.com | Andrew Sherwood |James A. Blumenthal |Robert J. Mentz |Gary G. Koch

Introduction Elevated depressive symptoms have been found to be associated with a marked increase in adverse clinical outcomes for heart failure (HF) patients with reduced ejection fraction (HFrEF).1-3 The increased risk of adverse clinical outcomes associated with elevated depressive symptoms in HFrEF patients is substantial, even in the absence of levels that denote clinical depression.3-6 There is also evidence that depressive symptoms that increase or worsen over time may signal HF...

Mar 11, 2024 | onlinelibrary.wiley.com | Andrew Sherwood |Christi S. Ulmer |Jade Wu |James A. Blumenthal

1 BACKGROUND There is a growing body of evidence that insomnia is a cardiovascular disease (CVD) risk factor. In a meta-analysis of 17 observational cohort studies, with a combined sample size of 311,260 participants free of CVD at baseline, Li and colleagues1 found that insomnia was associated with a 41% increased risk of myocardial infarction (MI), coronary heart disease (CHD), stroke, or CVD mortality over a 1-year follow-up period.