James A. Bonner

Oct 29, 2024 | nature.com | Hongxing Shen |Oluwagbemiga Ojo |Haitao Ding |Zach Lewis |Ewa Podgorska |James A. Bonner

AbstractHypoxia is a common feature in various pathophysiological contexts, including tumor microenvironment, and IFN-γ is instrumental for anti-tumor immunity. HIF1α has long been known as a primary regulator of cellular adaptive responses to hypoxia, but its role in IFN-γ induction in hypoxic T cells is unknown. Here, we show that the HIF1α-glycolysis axis controls IFN-γ induction in both human and mouse T cells, activated under hypoxia.