Jamie R. Blundell

Mar 5, 2025 | nature.com | Chiraag Kapadia |Nicholas Williams |Caroline Watson |Matthew J. Yousefzadeh |Kudzai Nyamondo |Alex Cagan | +8 more

AbstractHaematopoietic stem cells maintain blood production throughout life1. Although extensively characterized using the laboratory mouse, little is known about clonal selection and population dynamics of the haematopoietic stem cell pool during murine ageing. We isolated stem cells and progenitors from young and old mice, identifying 221,890 somatic mutations genome-wide in 1,845 single-cell-derived colonies.

Sep 11, 2023 | nature.com | Caroline Watson |Jamie R. Blundell

AbstractMosaic chromosomal alterations (mCAs) are common in cancers and can arise decades before diagnosis. A quantitative understanding of the rate at which these events occur, and their functional consequences, could improve cancer risk prediction and our understanding of somatic evolution.