Jan Ellenberg

Oct 17, 2024 | embl.org | Matthew Hartley |Christoph Müller |Jan Ellenberg

A closer look at 50 years of imaging developments at EMBL By Matthew Hartley, Christoph Müller, and Jan EllenbergIn the late 1970s, John Kendrew, EMBL’s first Director General, put Swiss biophysicist Jacques Dubochet in charge of the ‘Laboratory for Electron Microscopy Applications’. The aim was to set up methods for carrying out electron microscopy at very, very low temperatures.

Nov 6, 2023 | nature.com | Yuki Hayashi |Ievgeniia Zagoriy |Jan Ellenberg |Christoph Müller |Sara Cuylen-Haering

AbstractCryo-electron tomography (cryo-ET) allows for label-free high-resolution imaging of macromolecular assemblies in their native cellular context. However, the localization of macromolecules of interest in tomographic volumes can be challenging. Here we present a ligand-inducible labeling strategy for intracellular proteins based on fluorescent, 25-nm-sized, genetically encoded multimeric particles (GEMs).

Jul 11, 2023 | nature.com | Matthew Hartley |Jan Ellenberg

The future of bioimage analysis is increasingly defined by the development and use of tools that rely on deep learning and artificial intelligence (AI). For this trend to continue in a way most useful for stimulating scientific progress, it will require our multidisciplinary community to work together, establish FAIR (findable, accessible, interoperable and reusable) data sharing and deliver usable and reproducible analytical tools.