Janith A. Seneviratne

2 months ago | biorxiv.org | Janith A. Seneviratne |Eleanor Glancy |Natalie Choy |Clare L Crisp

AbstractEmbryonic regulators are often re-expressed in cancers, however the functional and molecular significance of this is not always understood. The epigenetic priming factors Developmental Pluripotency Associated 2 and 4 (DPPA2/4) have crucial roles in early development and are implicated in cancer pathogenesis.

Oct 13, 2024 | nature.com | Belamy B. Cheung |Qian Wang |Janith A. Seneviratne |Andrew Gifford |Chelsea Mayoh |Lin Luo | +8 more

AbstractMYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on the germline of neuroblastoma-prone TH-MYCN transgenic mice to generate founders which had lost tumorigenesis. Sequencing of the mutant mouse genomes identified the Ring Finger Protein 121 (RNF121WT) gene mutated to RNFM158R associated with heritable loss of tumorigenicity.