Janith A. Seneviratne

Oct 13, 2024 | nature.com | Belamy B. Cheung |Qian Wang |Janith A. Seneviratne |Andrew Gifford |Chelsea Mayoh |Lin Luo | +8 more

AbstractMYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on the germline of neuroblastoma-prone TH-MYCN transgenic mice to generate founders which had lost tumorigenesis. Sequencing of the mutant mouse genomes identified the Ring Finger Protein 121 (RNF121WT) gene mutated to RNFM158R associated with heritable loss of tumorigenicity.