Josep M. Mercader

May 15, 2024 | newsgram.com | Josep M. Mercader

Artificial Intelligence:- The idea that biology is not destiny is hardly new. Studies in twins have shown that even among identical pairs — those sharing 100 percent of their DNA — the same disease genes do not turn into full-blown illness in both individuals. Most human diseases are fueled by both genetic and environmental factors. Genes account for 30 to 70 percent of the risk for developing conditions such as type 1 diabetes, hypertension, stroke, or Parkinson’s disease.

Apr 26, 2024 | genomemedicine.biomedcentral.com | Ravi Mandla |Philip Schroeder |Bianca Porneala |Jose C. Florez |James B. Meigs |Josep M. Mercader | +1 more

We sought to evaluate the longitudinal predictive performance of T2D PGS for incident T2D by creating simulated scenarios that varied in depth of clinical data availability at the time of each patient’s initial clinical encounter in the MGH PCP network. We extracted two decades of clinical data for 284,602 patients who had received primary care through the network from an EHR repository including outpatient, emergency department, and inpatient visits.

Feb 19, 2024 | nature.com | Konstantinos Hatzikotoulas |Henry Taylor |Xianyong Yin |Kim Lorenz |Mark McCarthy |Anubha Mahajan | +6 more

AbstractType 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D.

Jan 25, 2024 | nature.com | Soo Heon Kwak |Josep M. Mercader |Jose C. Florez |Jason Flannick

AbstractThe prevalence of youth-onset type 2 diabetes (T2D) and childhood obesity has been rising steadily1, producing a growing public health concern1 that disproportionately affects minority groups2. The genetic basis of youth-onset T2D and its relationship to other forms of diabetes are unclear3.