Javier Martín

Jul 15, 2024 | nature.com | Olivia Castellini-Pérez |Guillermo Barturen |Martin Kerick |Raúl López-Domínguez |Javier Martin |Javier Martín | +3 more

AbstractThe heterogeneity of systemic lupus erythematosus (SLE) can be explained by epigenetic alterations that disrupt transcriptional programs mediating environmental and genetic risk. This study evaluated the epigenetic contribution to SLE heterogeneity considering molecular and serological subtypes, genetics and transcriptional status, followed by drug target discovery.

Dec 2, 2023 | mdpi.com | Javier Martin |Javier Martín |Andrea Sanchez |Irene Marco |Esther Mancebo Sierra

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Oct 5, 2023 | mdpi.com | Laura Bubba |Soile Blomqvist |Erwin Duizer |Javier Martin |Javier Martín

1. IntroductionEnteroviruses (EVs) are members of the Picornaviridae family, with over 110 types known to infect humans, belonging to species A–D. The most well-known EV is poliovirus (PV), belonging to species C, which can cause acute flaccid paralysis (AFP, also known as polio or poliomyelitis). PV encompasses three serotypes, and thanks to the effort of the Global Polio Eradication Initiative (GPEI) programme, wild-type PV (WPV) is currently only endemic in Afghanistan and Pakistan [].

Jun 9, 2023 | nature.com | Anika Singanayagam |Cristina C. Celma |Javier Martin |Javier Martín |Benjamin Shillitoe

AbstractIncreasing detections of vaccine-derived poliovirus (VDPV) globally, including in countries previously declared polio free, is a public health emergency of international concern. Individuals with primary immunodeficiency (PID) can excrete polioviruses for prolonged periods, which could act as a source of cryptic transmission of viruses with potential to cause neurological disease.