Jawad H. Butt

Oct 11, 2024 | jacc.org | Jawad H. Butt |Alasdair Henderson |Pardeep S. Jhund |Brian Claggett

Introduction Aldosterone is secreted by the adrenal glands and regulated by circulating angiotensin II and serum potassium concentration, and the deleterious consequences of excessive production of this hormone (and mineralocorticoid receptor overactivation) on the heart, vasculature, and kidney are well-established.1-5 However, aldosterone synthase is also expressed in adipocytes, which can secrete aldosterone, and angiotensin II is produced in adipose tissue and stimulates the production of...

Dec 28, 2023 | jamanetwork.com | Pardeep S. Jhund |Brian Claggett |Atefeh Talebi |Jawad H. Butt

Key PointsQuestion  Does dapagliflozin reduce the risk of total episodes of worsening heart failure (HF; defined as hospitalization for HF or urgent HF visit requiring intravenous HF therapies) and cardiovascular death in patients with mildly reduced or preserved ejection fraction heart failure?

Nov 17, 2023 | jamanetwork.com | Eva Havers-Borgersen |Jawad H. Butt |Marianne Johansen |Olav Bjørn Petersen

Key PointsQuestion  Are women with a history of preeclampsia at increased risk of venous thromboembolism? Findings  This nationwide cohort study of 522 545 primiparous women found that preeclampsia was associated with an increased risk of venous thromboembolism during pregnancy, during the puerperium, and after the puerperium, even after comprehensive adjustment for potential confounders.

Oct 9, 2023 | onlinelibrary.wiley.com | Jawad H. Butt |Kirsty McDowell |Toru Kondo |Akshay S. Desai

Introduction Red cell distribution width (RDW) is a measure of the heterogeneity in the size of circulating red cells, and it is routinely assessed as part of a complete blood cell count, but not always reported.1, 2 RDW is calculated by dividing the standard deviation of the red blood cell volume by the mean corpuscular volume multiplied by 100.1, 2 Higher RDW values reflect greater heterogeneity in red blood cell size (i.e. anisocytosis), and, together with other measures, it has...

Oct 1, 2023 | jacc.org | Jawad H. Butt |Kieran F. Docherty |Mikhail Kosiborod |Silvio E. Inzucchi

1. "Health related quality of life in patients with congestive heart failure: comparison with other chronic diseases and relation to functional variables". Heart . 2002;87:235-241. 2. "Quality of life and symptoms of depression in advanced heart failure patients and their partners". Curr Opin Support Palliat Care . 2010;4:233-237. 3. "The MacNew heart disease health-related quality of life instrument: reference data for users". Qual Life Res . 2002;11:173-183. 4.