Jay D. Keasling

Feb 23, 2024 | cell.com | Jay D. Keasling |Kongens Lyngby |Shenzhen Institutes

Department of Food Science and Biotechnology, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea Biofoundry Research Center, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea Department of MetaBioHealth, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA Joint BioEnergy...

Jan 16, 2024 | cell.com | Rong Chen |Hangzhou Normal |Ming Wang |Jay D. Keasling

Highlights Terpenoids have extensive pharmacological activities and are extensively applied in the pharmaceutical, cosmetic, and food industries. Increasing the structural diversity of terpenoids would expand their potential applications. Noncanonical backbones can be generated by coexpressing the canonical mevalonate pathway and C-methyltransferases, or the lepidopteran mevalonate pathway, in engineered strains.

Dec 10, 2023 | nature.com | Han Yu |Jay D. Keasling

AbstractPrediction of enzyme kinetic parameters is essential for designing and optimizing enzymes for various biotechnological and industrial applications, but the limited performance of current prediction tools on diverse tasks hinders their practical applications.

Dec 4, 2023 | nature.com | Hongting Tang |Xiaozhou Luo |Jie Zeng |Jay D. Keasling

AbstractThe increase in population-related and environmental issues has emphasized the need for more efficient and sustainable production strategies for foods and chemicals. Carbohydrates are macronutrients sourced from crops and undergone transformation into various products ranging from foods to chemicals.

Nov 12, 2023 | nature.com | Hongting Tang |Jay D. Keasling

AbstractJasmonates are a class of plant hormones with many agricultural applications and potential medicinal properties. However, the low content of jasmonates in plants and environmental issues with their production make their supply challenging. In the present study, we report the de novo microbial biosynthesis of jasmonic acid and its derivatives, methyl jasmonate and jasmonoyl isoleucine, from glucose using an engineered baker’s yeast.