Jeff Bronstein

Jun 12, 2023 | jamanetwork.com | Jeff Bronstein |William A. Zeiger |Chao Peng |Alberto J Espay

Abandoning the Proteinopathy Paradigm in Parkinson Disease—Not So Fast To the Editor Espay and Okun1 recently proposed abandoning the proteinopathy paradigm in Parkinson disease (PD) in favor of a “proteinopenia” hypothesis. Loss of function as a possible mechanism for PD and other neurodegenerative diseases is not a new idea, and we agree that multiple potential mechanisms underlying neurodegeneration should be investigated.